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Extended applications deadline for the 2024 IAPIDS Advanced Clinical Immunology Training and Career Building!
Apply Today for the 2024 IAPIDS Training Course!
Dear ESID Junior Members,
We are pleased to inform you that the October 2023 Call for ESID Fellowships is now open! Please, visit the Fellowships page for more information.
The ESID Administrative office
We are pleased to announce on behalf of the Transatlantic Gene Therapy Consortium that the 13th Stem Cell Clonality and Genome Stability Retreat will take place on October 23th, 2023 in Brussels, Belgium.
The program of the event is available here .
We are pleased to share information about the "KID_interferon" project, provided by Lorenzo Lodi.
Brief rationale of the project:
Monogenic type I interferonopathies (T1I) (like COPA syndrome (COPA), STING-associated vasculopathy with onset in infancy (SAVI) or some monogenic lupus) may display renal involvement. These entities are characterized by a systemic upregulation of type I interferons (IFN-I) which is central to the disease pathogenesis. However, a clear documentation of IFN-I upregulation at tissue level is still lacking. Indeed, this would be crucial to understand the selective organ involvement encountered in these diseases. The demonstration of tissue IFN-I upregulation can be performed applying human myxovirus resistance protein 1 (MxA) immunostaining to renal biopsies. While this characterization has been assessed in a few patients with T1I-related kidney diseases, it has never been performed in SAVI, COPA and several others T1I.
Here you can find more details about the project.
We are excited to announce that the 22nd Biennial Meeting of ESID will be held in 2026 in Maastricht, The Netherlands!
It is with great sadness that we learned of the tragic and death of our colleague, Oksana Leontieva, a pediatric hematologist from Ukraine and a victim of a recent missile strike in Kyiv ( https://www.telegraph.co.uk/world-news/2022/10/11/ukraine-russia-war-oksana-leontyeva-killed-air-strikes-kyiv/).
We at ESID offer our deepest condolences to her family, friends and colleagues of the National Pediatric Ohmatdyt Hospital.
We take this somber moment to send our thoughts and prayers in the memory of all other fellow humans who needlessly perished as a result of the current war.
COPA syndrome is a recently defined type I interferonopathy caused by heterozygous mutations in the gene COPA, encoding coatomer protein subunit alpha that is involved in intra-cellular transport of cargo proteins1. Although the pathogenesis is not fully understood, mutations in COPA were shown to cause an accumulation of STING at the Golgi2 where it is activated and leads to constitutive type I interferon signalling i.e. the core feature of type I interferonopathies.
ESID registry Working Party is inviting the ESID registry participants to take part in the "Malignancies in IEI" study latest by August 31st 2022.
The IDDA score has already been available as optional module (tab) in the level 1 for your own use at the initial and follow up patient entries and is designed for all IEI with immune dysregulation. Now, I am inviting your active contribution to a prospective study until end of 2023 (prolongation possible), aiming to implement a powerful tool for assessment and monitoring of disease activity and phenotype patterns!